Anthracycline Chemistry and Biology II: Mode of Action, by Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn

By Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn (eds.)

see desk of contents

Show description

Read or Download Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs PDF

Best chemistry books

Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects

This completely listed booklet summarizes a wealth of knowledge at the biochemical goals of plant protective compounds, and is an a useful reference for all biomedical pros.

Hydrogeochemische Stoffflussmodelle: Leitfaden zur Modellierung der Beschaffenheitsentwicklung von Grund- und Rohwassern (German Edition)

Leichter Einstieg: Bei Grundwasservorkommen, die zur Trinkwasserversorgung genutzt werden, gewinnen Aspekte der Wasserbeschaffenheit zunehmend an Bedeutung. Wer geochemische Prozesse versteht, kann diese bewerten und managen. Der lehrbuchartige Aufbau stellt Grundlagen und Hintergrundinformationen in shape kurzer Exkurse vor.

The Biological Chemistry of Iron: A Look at the Metabolism of Iron and Its Subsequent Uses in Living Organisms Proceedings of the NATO Advanced Study Institute held at Edmonton, Alberta, Canada, August 13 – September 4, 1981

The result of a NATO complicated research Institute (ASI) entitled "Coordination Chemistry Environments in Iron-Containing Proteins and Enzymes - together with Smaller Molecules and version structures" are summarized during this e-book. The ASI used to be held within the Province of Alberta, Canada, from August 23 to September four, 1981.

Additional info for Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs

Example text

Schrijvers D, Bos AM, Dyck J, de Vries EG, Wanders J, Roelvink M, Fumoleau P, Bortini S, Vermorken JB (2002) Ann Oncol 13:385 72. Caponigro F, Willemse P, Sorio R, Floquet A, van Belle S, Demol J, Tamburo R, Comandino A, Capriati A, Adank S, Wanders J (2005) New Drugs 23:85 73. Fiedler W, Tchen N, Bloch J, Fargeot P, Sorio R, Vermorken JB, Collette L, Lacombe D, Twelves C (2006) Eur J Cancer 42:200 44 P. Menna et al. 74. Reszka KJ, Britigan LH, Britigan BE (2005) J Pharmacol Exp Ther 315:283 75.

36 36 38 References . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . Abstract The clinical use of doxorubicin and other quinone-hydroquinone anticancer anthracyclines is limited by a dose-related cardiotoxicity. Here, we review the correlation of cardiotoxicity of doxorubicin with its peak plasma concentration and diffusion in the heart, followed by reductive bioactivation or oxidative inactivation. One-electron quinone reduction and two-electron side chain carbonyl reduction are accompanied by iron and free radical reactions that are responsible for many aspects of anthracycline cardiotoxicity.

4 Translating the Metabolic Determinants of Cardiotoxicity into Protective Strategies Antioxidants . . . . . . . . . Iron Chelators . . . . . . . . Noncardiotoxic Anthracycline Analogs . Modulators of Anthracycline Degradation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Cardiotoxic Synergism of Anthracyclines with Other Drugs . . . . Anthracyclines and Taxanes . . . . . . . . .

Download PDF sample

Rated 4.93 of 5 – based on 42 votes