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Extra resources for Annual Review of Immunology Volume 17 1999

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Annu. Rev. Immunol. 17:19-49. org by HINARI on 08/31/07. For personal use only. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 9:56 QC: NBL/tkj T1: NBL Annual Reviews AR078-02 WALDMANN & TAGAYA response to iron. Proc. Natl. Acad. Sci. USA 84:6730–34 Chu E, Voeller D, Koeller DM, Drake JC, Takimoto CH, Maley GF, Maley F, Allegra CJ. 1993. Identification of an RNA binding site for human thymidylate synthase. Proc. Natl. Acad. Sci. USA 90:517– 21 Mosner J, Mummenbrauer T, Bauer C, Sczakiel G, Grosse F, Deppert W.

J. Immunol. 158:800–6 45 58. Washizu J, Nishimura H, Nakamura N, Nimura Y, Yoshikai Y. 1998. The NFkappa B binding site is essential for translational activation of the IL-15 gene. Immunogenetics 48:1–7 59. Kozak M. 1987. An analysis of 5 noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125–48 60. Kozak M. 1991. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:887–903 61. Kozak M. 1992. A consideration of alternative models for the initiation of translation in eukaryotes.

Immunol. 17:19-49. org by HINARI on 08/31/07. For personal use only. IL-15 AND ITS RECEPTORS 35 IL-15 contributed to the anticryptococcal activity of macrophages (54). IL-15 induces IL-8 and monocyte chemotactic protein-1 production in human monocytes (112). Furthermore, although neither IL-12 nor IL-15 addition resulted in the induction of IFN-γ production by either NK cells or γ δ T cells, they acted synergistically on these cells, inducing the production of IFN-γ , TNF-α, and GM-CSF (53). Finally, IL-15 mRNA and protein were most highly expressed in patients with immunologically resistant tuberculoid leprosy but not in unresponsive and susceptible lepromatous patients (57).

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