By Desmurs J.-R., Gerard B., Goldstein M.J.
The natural molecules which are used, really within the components of pharmacy and agrochemicals, have gotten a growing number of advanced either of their chemical nature and spacial configuration. a fancy molecular constitution is necessarily fragile; it can't be produced below serious stipulations (in specific excessive strain and temperature). additionally there's a challenge of the scale-up of a product from the laboratory to the economic scale. The regulate of the reactivity, selectivity, and yield and using sufficiently gentle business stipulations are all components that has to be taken under consideration by way of business chemists. among the ''tools'' giving controllable reactivity, selectivity, and comparatively light response stipulations is bromine. The natural chemistry of bromine occasionally provides unbelievable selectivities in comparison to these of chlorine. This quantity that is in line with ''Orgabrom '93'', brings jointly the most contributions provided at this occasion.
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Example text
The reaction did not proceed in ethanol to be due to the elution of copper(II) bromide from the alumina to the solution. It is known that the reaction of aromatic hydrocarbons with copper(II) halides in nonpolar solvents proceeds between aromatic hydrocarbons and solid copper(II) halides and not between hydrocarbons and dissolved copper(II) halides (ref. 6). 22 Bromination of 1-Alkoxynaphtalenes The reaction of 1-alkoxynaphtalenes with copper (II) bromide in benzene produced a mixture of 4-bromo-l-alkoxynaphtalenes and 4,4'-dialkoxy-l,l'binaphtyls.
1-Alkoxynaphtalenes react with copper(II) bromide in heterogeneous conditions to give a mixture of 4-bromo-1alkoxynaphtalenes and 4,4'-dialkoxy-1, l'-binaphtyls. Previously, we reported that copper(II) halides can be activated remarkably by supporting onto neutral alumina, and halogenated phenylacetylene selectively to give 1-halo-2-phenylacetylene or 1,1,2-trihalo-2-phenyl-ethylene in non polar solvents under mild conditions (ref. 8). Here, we report that a facile method for selective nuclear bromination of aromatic compounds (polymethylbenzenes, polycyclic aromatic hydrocarbons, alkoxybenzenes, alkoxynaphtalenes and alkoxythionaphtalenes) by use of aluminasupported copper(II) bromide.
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